The main goal of our research is to define the regulation of adaptive immune responses during inflammation within the central nervous system (CNS). The Wu lab has several areas of ongoing investigation into the pathogenesis of multiple sclerosis (MS) and related diseases. We are exploring various immunologic abnormalities in MS by examining characteristics of circulating B cells and monocytes from patients. In addition, we are modeling cellular and molecular immune contributions to neuro-inflammation by primarily utilizing murine experimental autoimmune encephalomyelitis (EAE). Finally, we are actively engaged in several clinical trials to identify potential new highly efficacious disease-modifying therapies and mechanisms of action for currently approved MS therapies.

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B Cell Antigen Presentation
Compartmentalized CNS Antigen Access
TRPV4 in EAE and MS
Optic Neuritis